Publications

2021

Long-read whole genome sequencing reveals HOXD13 alterations in synpolydactyly

VIP152 Is a Novel CDK9 Inhibitor with Efficacy in Chronic Lymphocytic Leukemia

Long-read whole genome sequencing reveals HOXD13 alterations in synpolydactyly

Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

2020

A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome

TP-0903 is active in models of drug-resistant acute myeloid leukemia

Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A

Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 Expression

Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A

Large-Scale Drug Screen Identifies FDA-Approved Drugs for Repurposing in Sickle-Cell Disease

Cotargeting of XPO1 Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Acute Myeloid Leukemia

LC-FACSeq is a method for detecting rare clones in leukemia

Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BTK/PLCG2 mutations

Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BTK/PLCG2 mutations

Quantifying Hematopoietic Stem Cell Clonal Diversity by Selecting Informative Amplicon Barcodes

Transcriptionally Active Androgen Receptor Splice Variants Promote Hepatocellular

Characterization and mitigation of fragmentation enzyme-induced dual stranded artifacts

2019

Enumerating Functional HSC Clones in the Zebrafish Using Gestalt

Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia

LC-Facseq: A Novel Method for Detecting Rare Resistant Clones in Leukemia

NPM1 mutations Using Deep Amplicon Sequencing and Broad Next Generation Sequencing at the Time of Complete Remission Is Informative to Predicting Risk of Relapse Following Intensive Chemotherapy

Rapid Molecular Diagnostics for Acute Myeloid Leukemia

Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia

Clinical and molecular characterization of patients with acute myeloid leukemia and sole trisomies of chromosomes 4, 8, 11, 13 or 21

Developmental subtypes assessed by DNA methylation-iPLEX forecast the natural history of chronic lymphocytic leukemia

BRCA1/2 Functional Loss Defines a Targetable Subset

Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML

Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically

2018

Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL

NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome

Uncovering the Genomic Landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically Normal FLT3-ITD AML

Genomic amplification of CDK4 in dedifferentiated liposarcomas

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor

Mutation patterns identify adult patients with de novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: an analysis of Alliance studies

2017

Landscape of Microsatellite Instability Across 39 Cancer Types

Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma

Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib

Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors

Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients

The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia

The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia

Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality

Performance evaluation for rapid detection of pan-cancer microsatellite instability with MANTIS

2016

Interferon-γ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells*

Targeting BTK through microRNA in chronic lymphocytic leukemia

Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia

MonoSeq Variant Caller Reveals Novel Mononucleotide Run Indel Mutations in Tumors with Defective DNA Mismatch Repair

Persistence of DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukaemia

Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2

Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifi es miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia

Structural characterization of NRAS isoform 5

HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia

2015

Clinical features and gene- and microRNA-expression patterns in adult acute leukemia patients with t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3)

Cancer Driver Log (CanDL) Catalog of Potentially Actionable Cancer Mutations

MuCor: mutation aggregation and correlation

Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia

2014

PKC-b as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL

PrEMeR-CG: inferring nucleotide level DNA methylation values from MethylCap-seq data

Persistence of DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukaemia

2013

Emerging Drug Profile: Cyclin-Dependent Kinase Inhibitors