BLACHLY LAB

Leverage emerging genome technologies to advance the understanding and treatment of leukemia

About

We pride ourselves on using the most cutting edge technologies to aid in research of leukemia. Our hope is the research we do directly impacts the understanding and treatment of leukemia, generating better outcomes for patients in the future. Checkout more about our tools on our GitHub or checkout what the lab has been up to in our Blog.

Mission

The Blachly Lab’s mission is to advance research in understanding the role genetics and genomics play in the development, progression and treatment of blood cancers — especially acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL) — and return that information back to the clinic, informing the design of future clinical trials to improve patient care.

Approach

Members of the lab collaborate broadly with other scientists to help use bioinformatics and computational biology to answer important questions about cancer - a majority of this collaborative work also focused in leukemia. Software developed in the lab is broadly applicable in cancer research aiding in the lab’s own leukemia-focused work; we use our tools and those of the scientific community to examine functional genomic biomarkers from clinical trials to help inform contemporary treatment and guide the development of future therapeutics.

Assortment of tools developed in the Blachly Lab including (but not exlusive to) DHtslib, Fade, Swiftover, Mucor3, and Recontig

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Finished Research Projects

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Ongoing Projects and Collaborations

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Long-read whole genome sequencing reveals HOXD13 alterations in synpolydactyly

VIP152 Is a Novel CDK9 Inhibitor with Efficacy in Chronic Lymphocytic Leukemia

Long-read whole genome sequencing reveals HOXD13 alterations in synpolydactyly

Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia

A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high‐risk myelodysplastic syndrome

More Publications

ctDNA as a Biomarker in Hairy Cell Leukemia

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Why Dr. Blachly chose a career as a hematologist

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Esko Kautto

Ph.D. candidate, Ohio State University

James Blachly

Assistant Professor, Ohio State University

Kathryn Kananen

Biomedical Informatics Specialis, Ohio State University

Thomas Gregory

Biomedical Informatics Specialist, Ohio State University

Full team

We gratefully acknowledge financial support from our sponsors:

OSTOR
ASTOR
HCLF
SASS
NCCN
PELO
OSUSC
SR